Bleomycin

Chemistry of bleomycin. XIX Revised structures of bleomycin and phleomycin.

Bleomycin-Induced Flagellate Dermatitis

Flagellate dermatitis is an uncommon cutaneous drug reaction with a characteristic whip-like appearance that occurs in the setting of bleomycin administration, an agent used in chemotherapy. Bleomycin toxicity is frequently dose-related and lesions typically disappear after discontinuation of the drug although residual hyperpigmentation can remain. Due to the number of patients undergoing treat...

Bleomycin: A worthy alternative

CONTEXT Lymphangiomas are developmental anomalies presenting mainly in the first two years of life. Surgical excision has been the mainstay of treatment; however a potentially disfiguring surgery along with presence of important structures in the vicinity and infiltration into surrounding structures makes the dissection difficult. AIMS To study the safety and efficacy of Bleomycin as a sclero...

Bleomycin-induced flagellate hyperpigmentation.

Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.

Flagellate hyperpigmentation from bleomycin.

Sir, Mucocutaneous side effects associated with bleomycin are stomatitis, ulcers, scaly erythematous and bullous lesions, sclerosis, nail changes, digital gangrene and pigmentary alterations. Hyperpigmentation occurring mainly on the pressure areas of the skin as well as in areas of scratch marks is seen in approximately 30% of patients. Flagellate hyperpigmentation is very characteristic of bl...